Choosing NSAID Therapy

Summing the risk of NSAID therapy.

1 Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006; 368: 1271–83. 2 Guillet R, Stoll BJ, Cotton CM, et al. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics 2006; 117: e137–42. 3 Holman RC, Stoll BJ, Curns AT, et al. Necrotising enterocolitis hospitalisations among neonates in the United States. Paediatr Pern...

Choosing Targets for Gene Therapy

Choosing Initial Therapy for Hypertension

With numerous safe and effective antihypertensive drugs now available, the clinician should no longer choose only diuretic agents or /3-adrenergic receptor blockers (/3-blockers) as initial therapy. Five classes of agents, including angiotensin converting enzyme inhibitors, /3-blockers, calcium entry blockers, peripheral a,-adrenergic receptor blockers, and thiazide diuretic agents, are all app...

Experience with misoprostol therapy for NSAID gastropathy in children.

OBJECTIVE To determine the effect of misoprostol, a synthetic prostaglandin E1 analogue, on the gastrointestinal tract (GIT) symptoms associated with non-steroidal anti-inflammatory drug (NSAID) administration and on the haemoglobin value, in children. METHODS Retrospective chart review of children attending the paediatric rheumatology clinic at a tertiary referral hospital over a three year ...

Tailoring arthritis therapy in the wake of the NSAID crisis.

ble, and it would reduce rather than increase public expenditures. Well-targeted federally funded medication trials can more than pay for themselves; examples to date include NIH-supported studies of estrogen replacement and of medications for hyper-tension, which provided important insights into the risks, benefits, and optimal use of these therapies. These needed insights can improve care and...